CELLULAR AND METABOLIC CHARACTERISTICS OF PRE-LEUKEMIC HEMATOPOIETIC PROGENITORS WITH GATA2 HAPLOINSUFFICIENCY

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency

Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85% of carriers.How a partial loss of GATA2 functionality enables leukemic transformation years later is unclear.This question has remained unsolved mainly due

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Giant gastric lipoma mimicking well-differentiated liposarcoma

Authors report the case of a 51-year-old man, presenting with epigastralgia of recent onset.Physical exam was unremarkable.Endoscopy revealed a large, ulcerated, submucosal, antral tumor.CT scan reveals an antral mass with fat attenuation.The patient underwent a total gastrectomy.Macroscopic examination identified in the antral wall a 9-cm, well-ci

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Quick-Response Model for Pre- and Post-Disaster Evacuation and Aid Distribution: The Case of the Tula River Flood Event

Background: In the context of humanitarian logistics, efficiently evacuating people from disaster-stricken areas ONE PIECE is a complex challenge.This study focuses on the Tula River region in Hidalgo, Mexico, exploring the evacuation and support of individuals in temporary shelters.Despite the fact that the topic has been addressed in the literatu

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